Chromatography - Some Objectives of Using CAE
- Understand effects of distributor and collector designs and
process parameters on flow field.
- Define a system that provides "plug flow".
- Eliminate back mixing in distribution system
|
|
Some Benefits of Using CAE
- Identify key physical design parameters to increase
performance.
- Identify process parameters that does not have a significant
effect on system performance. (e.g., the equipment design was
controlling a parameter).
|
|
Process Parameters
- Flow rate
- Inlet velocity
- Screen permeability
- Packed bed permeability
- Distributor & collector geometry
|
|
Chromatography Calculations Using Passage Software
- Velocity field inside column
- Determine flow uniformity, plug flow
- Locate channeling & vortexing regions
- Back mixing in distributors
- Statistical analysis of velocity variations
- Degree of velocity variation and percentage of column
affected
- Performance comparison of different column configurations
|
|
| |
|
| |
|